Home » Aging »Context »Diet/Insulin »Environment »Gut Flora/Bacteria »Mental Health »Neuroplasticity »Personal Health »Pioneers »Resources »Social Environment »Stress/Cortisol » Currently Reading:

Inflammation – The deep cause of so much chronic illness and even dementia

It is becoming increasingly accepted that most chronic illness – no matter how different in its expression – has causal roots in inflammation. Much of the early work on this has involved diet. But recently many more aspects of how we live have entered the mix – stress, sleep, relationships, when we eat as well as what we eat.

This post, By James P Watson, with contributions and editorial assistance by Vince Giuliano, is the most comprehensive that I have seen yet and stands as a benchmark for advice on the process and for what each of us can do to reduce our chances of developing chronic illness and dementia.

INTRODUCTION AND OVERALL PRINCIPLES

This is the first of a pair of blog entries concerned with dementias – neurological diseases including Alzheimer’s Disease (AD) and its cousins.  This Part 1 write-up was inspired by a recent small, non-randomized clinical trial done by Dr. Dale Bredesen that showed true “Reversal of Cognitive Decline” in 9 out of 10 patients with documented cognitive decline (Bredesen, 2014).  Not all of these patients had AD, but all had cognitive decline.  Five had AD, two had SCI (subjective cognitive impairment), and two had MCI (mild cognitive impairment).  Although this study was too small to allow any statistical conclusions, it is the most positive report in a series of disappointing reports on the recent failures of Big Pharma’s monoclonal antibodies against amyloid-beta.  Dale Bredesen’s approach was a multifactorial one – utilizing 24 different approaches to halt or reverse cognitive decline.  We explore those 25 interventions here, focusing on the first 19.  They do not depend on drugs.   The focus of this blog entry is “What can be done about dementias now?”

The forthcoming Part 2 blog entry will provides a detailed discussion of some of the key science related to AD and dementias.  This is the “What is science telling us about dementias?” part which gets quite complex.  We review major theories related to AD there including the Hardy Hypothesis related to amloid beta, the GSK3 theory and more detail on the neuroinflammation theory which we introduce in this Part 1 blog entry.  We expect to emphasize the emerging importance APP (Amloid Precursor Protein).  And we will describe some very recent research that appears to establish that a basic cause of AD is the proliferation in aging of vestigal DNA segments in our genomes (known as LINEs which are long interspersed nuclear elements and SINEs which are short interspersed nuclear elements) with encode over and over again for the production of APP and for the failure of its clearance.  This could well finally explain the role of beta amyloid in AD.

We have published a number of earlier blog entries relating to AD and dementias.  For example, you might want to review my August 2014 blog entry The Amyloid Beta face of Alzheimer’s Disease.

The full post continues here

 

Comment on this Article:







Contact Form

Subscribe by Email

Enter your email address:

Delivered by FeedBurner

Facebook

Comments

  • Susan: I wish I had known this information years ago. I am a second...
  • robpatrob: The link in in the post http://apps.npr.org/unfit-for-work...
  • Thibault: Very interesting blog, especially the link between disabilit...
  • Emma Johnson: Needed this to lighten the mood at the end of the day. Give...
  • RJ Jamieson: The mammary tissue was consumed repleat with raw milk drippi...
  • Anonymous: Your claim about wild fruit isn't 100% true. Read this artic...
  • Art: Staffan has recently passed away. We shall all miss him. Jan...
  • Jackie: This sounds great. But I was hoping that this article might ...
  • Phantom The God: Don't forget Coke damages your teeth and make your bones bri...
  • moon: Wow so many veganazis here... there was a study on 2 men who...
  • Christian DiMaria: This article seems to be exclusively focusing on sugar and c...
  • john: nital your a nitwit plain and simple how you have deluded...
  • Dane: But doesn't fructose take longer to process, thus allowing m...
  • cody f: let me set this straight.... Different humans are programmed...
  • cpu: An eclectivore diet seems best, meaning, eating a varieti-vo...

What is the Missing Human Manual All About?

Do you want to age well? Most of us do. If you are my age, 60, this is more important a question that if you are 30. But most of us would not wish to have heart disease, cancer, dementia when we get old.

Most of us think it is normal that we will get ill like this.

But science today tells us that this is not "Normal". Our evolutionary past designed us to be active and fit until we drop dead. Why? Because raising human children takes so long. Mature adults had to do most of the hard work enable us to invest up to 25 years in our kids.

We are designed by our evolution to reach a plateau of fitness in mid life. So why do most of us not live like this?

We don't because, we have strayed away from the best way of living that fits our evolution best. Our culture has got too far ahead of our biology. We eat foods that make us ill. We have lost our social identity and power and that makes us ill. And we have lost touch with the circadian rhythms of the Natural World, and that has made us ill too.

We have lost our fit with our true nature.

This site will be a Manual. It will show you what the best fit is. It will show you the science behind this. It will share with you some methods for getting your fit back with your true human nature.

So welcome to the "Missing Human Manual" . I hope that we can help you and I hope that you can help others as a result.

Featured Posts

Are humans carnivores?

For decades we have been told that grains and oils from seeds are the healthiest food we can eat. This has proved to be wrong. For decades we have been told to drink fruit juice as a healthy alternative. Now we know that it is as bad for us as …

Dr Jason Fung – On the Science of how we use food and so why fasting works

This is the clearest explanation I have yet found

Terminal Illness – Should we fight to the bitter end? If not what to do?

100 years ago, most deaths were quick. A person was well and then sick and then dead. Medicine could do very little. But today, most of us die long protracted deaths. Treatment is piled upon treatment. The dying person and their families endure increasing pain and humiliation and disappointment. Often …

%d bloggers like this: